nadolol and oxaprozin both increase serum potassium. Either increases toxicity of the other by Other (see comment). NSAIDs decrease prostaglandin synthesis. Avoid or Use Alternate Drug. Monitor Closely (1)nefazodone, oxaprozin. Avoid tanning booths and sunlamps. Therapeutic duplication ibuprofen IV and oxaprozin both increase serum potassium. oxaprozin, betrixaban. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. escitalopram, oxaprozin. Use Caution/Monitor.meclofenamate and oxaprozin both increase serum potassium. dabigatran and oxaprozin both increase anticoagulation. Minor (1)cefpirome will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Interaction mainly occurs in preterm infants. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Use Caution/Monitor.Minor (1)nabumetone will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. oxaprozin and succinylcholine both increase serum potassium. Interaction mainly occurs in preterm infants. Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Use Caution/Monitor.Minor (1)bendroflumethiazide will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Either increases toxicity of the other by anticoagulation. Use Caution/Monitor. Increased risk of upper GI bleeding. Mechanism: NSAIDs decrease prostaglandin synthesis, which normally protect against nephrotoxicity. Use Caution/Monitor.oxaprozin decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor.Minor (1)flurbiprofen will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. What is Meloxicam? oxaprozin will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Monitor Closely (1)azficel-T, oxaprozin. Use Caution/Monitor. Use Caution/Monitor. mefenamic acid and oxaprozin both increase anticoagulation. Minor/Significance Unknown. Either increases levels of the other by decreasing renal clearance. pharmacodynamic antagonism. . Minor/Significance Unknown. A key clinical question based on the AHRQ Effective Health Care Program systematic review of the literature is presented, followed by an evidence-based answer based on the review. ketorolac will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. oxaprozin increases and epinephrine decreases serum potassium. Monitor Closely (2)aspirin and oxaprozin both increase anticoagulation. candesartan and oxaprozin both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Therapeutic duplication, ibuprofen IV will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Monitor Closely (1)oxaprozin increases and epinephrine decreases serum potassium. Other (see comment). Monitor Closely (1)sertraline, oxaprozin. protamine and oxaprozin both increase anticoagulation. Monitor Closely (1)oxaprozin, fludrocortisone. Minor/Significance Unknown. Coadministration may result in a significant decrease in renal function. Monitor Closely (1)oxaprozin, cortisone. oxaprozin and sulfasalazine both increase anticoagulation. Avoid or Use Alternate Drug. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Minor (1)oxaprozin will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Either increases toxicity of the other by pharmacodynamic synergism. Immediate, unlimited access to all AFP content, Immediate, unlimited access to this issue's content. Use Caution/Monitor.meloxicam and oxaprozin both increase serum potassium. Use Caution/Monitor. levofloxacin, oxaprozin. Modify Therapy/Monitor Closely. All information is observation-only. Inferences for function were limited by the heterogeneous measures used across studies. Dysuria, Increased frequency of urination, Relative: bleeding disorder, duodenal/gastric/peptic ulcer, stomatitis, SLE, ulcerative colitis, upper GI disease, late pregnancy (may cause premature closure of ductus arteriosus), Use caution in asthma (bronchial), CHF, fluid retention, cardiac disease, severe hepatic impairment, hypertension, renal impairment, Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include the elderly, or those with impaired renal function, hypovolemia, heart failure, liver dysfunction, salt depletion, and individuals taking diuretics, ACE inhibitors, or ARBs, Factors that increase risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants; or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status, May cause drowsiness, dizziness, blurred vision, and other neurologic effects, which may impair physical or mental abilities; discontinue use and perform ophthalmologic exam with blurred or diminished vision occur, Therapy may increase risk of hyperkalemia in the elderly, renal disease, diabetes, and when used concomitantly with other agents capable of inducing hyperkalemia; monitor potassium levels closely, Mild photosensitivity reactions may occur, Use can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment; because of these risks, limit dose and duration of use between about 20 and 30 weeks gestation, and avoid use at about 30 weeks of gestation and later in pregnancy, Premature closure of fetal ductus arteriosus; use at about 30 weeks gestation or later in pregnancy increases risk of premature closure of fetal ductus arteriosus, Use of NSAIDs at about 20 weeks gestation or later in pregnancy has been associated with cases of fetal renal dysfunction leading to oligohydramnios, and in some cases, neonatal renal impairment, Data from observational studies regarding other potential embryofetal risks of NSAID use in women in first or second trimesters of pregnancy are inconclusive, The estimated background risk of major birth defects and miscarriage for indicated population(s) is unknown, Avoid use of NSAIDs in women at about 30 weeks gestation and later in pregnancy; NSAIDs can cause premature closure of fetal ductus arteriosus, If an NSAID is necessary at about 20 weeks gestation or later in pregnancy, limit use to the lowest effective dose and shortest duration possible; if treatment extends beyond 48 hours, consider monitoring with ultrasound for oligohydramnios, If oligohydramnios occurs, discontinue therapy and follow up according to clinical practice, There are no studies on effects of therapy during labor or delivery, Lactation studies have not been conducted; it is not known whether drug is excreted in human milk; drug should be administered to lactating women only if clearly indicated; developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for drug and any potential adverse effects on breastfed infant from drug or from underlying maternal condition. Use Caution/Monitor. Monitor Closely (2)ketoprofen and oxaprozin both increase anticoagulation. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Either increases toxicity of the other by decreasing renal clearance. oxaprozin and tolfenamic acid both increase serum potassium. Use Caution/Monitor.oxaprozin and sulfasalazine both increase serum potassium. Minor/Significance Unknown. oxaprozin and sulfasalazine both increase serum potassium. Effect of interaction is not clear, use caution. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. eprosartan, oxaprozin. Monitor Closely (2)oxaprozin decreases effects of bisoprolol by pharmacodynamic antagonism. Either increases effects of the other by anticoagulation. )Stop taking oxaprozin and get medical help right away if you notice any of the following rare but serious side effects: stomach/abdominal pain that doesn't go away, bloody or black/tarry stools, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, trouble speaking.Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication. Use Caution/Monitor. indomethacin and oxaprozin both increase serum potassium. Symptoms of overdose may include: severe stomach pain, vomit that looks like coffee grounds, extreme drowsiness, loss of consciousness, slowed or shallow breathing. Discuss the risks and benefits with your doctor or pharmacist.In certain conditions (such as arthritis), it may take up to 2 weeks when this drug is taken regularly before you notice the full benefits.Tell your doctor if your condition worsens. TYLER J. RAYMOND, DO, MPH, FAAFP, KRISTEN A. TOBIN, MD, AND TYLER S. ROGERS, MD, FAAFP, Madigan Army Medical Center, Tacoma, Washington. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonate and oxaprozin both increase serum potassium. Minor/Significance Unknown. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of oxaprozin by Other (see comment). losartan and oxaprozin both increase serum potassium. Meta-analyses were conducted when possible. Coadministration may result in a significant decrease in renal function. serotonin uptake by platelets. Use Caution/Monitor. Monitor Closely (1)latanoprostene bunod ophthalmic, oxaprozin. fluvoxamine, oxaprozin. Use Caution/Monitor. Monitor Closely (1)oxaprozin, budesonide. Monitor Closely (1)triamterene and oxaprozin both increase serum potassium. Use Caution/Monitor. Common side effects of Daypro include rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, fluid retention, and shortness of breath. Use Caution/Monitor. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Long term (>1 wk) NSAID use. oxaprozin, alendronate. fondaparinux and oxaprozin both increase anticoagulation. carvedilol and oxaprozin both increase serum potassium. aspirin rectal will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. cephalexin will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Monitor Closely (2)oxaprozin decreases effects of betaxolol by pharmacodynamic antagonism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvZGF5cHJvLW94YXByb3ppbi0zNDMyOTc=, View explanations for tiers and Either increases levels of the other by anticoagulation. Either increases toxicity of the other by pharmacodynamic synergism. Tiers and either increases toxicity of the other by other ( see comment ) protect against nephrotoxicity the by... 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