Cassandra Willyard 0 Cassandra Willyard Cassandra Willyard is a science journalist based in Madison, Wis. View author publications You can also search for this author in PubMed Google Scholar Twitter ecDNA hubs drive cooperative intermolecular oncogene expression [Hi-C] Genome binding/occupancy profiling by high throughput sequencing; Homo sapiens Expression profiling of macrophages reveals multiple populations with distinct biological roles in an immunocompetent orthotopic model of lung cancer. Thus, ecDNA hubs are nuclear bodies of many ecDNAs tethered by proteins and platforms for cooperative transcription, leveraging the power of oncogene diversification and combinatorial DNA interactions. 2021 Extchromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers Additionally, TMB, TIS, and PD-L1 expression levels were collected. The race is on to figure out why. Nucleic Acids Res. Gene induction typically involves cis-regulatory elements that contact and activate genes on the same chromosome. The 3D genome in transcriptional regulation and pluripotency. Article 24 NOV 21. Share This Paper. Tjian R, et al. Create Alert Alert. Structural basis for ligand reception by anaplastic lymphoma kinase. Cell Stem Cell 14, 762–775 (2014). Europe PMC is an archive of life sciences journal literature. Precision Oncology Ireland | 201 followers on LinkedIn. Gene induction typically involves cis-regulatory elements that contact and activate genes on the same chromosome. 1983 Nov 11; 11 (21):7631–7648. Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. ecDNA hubs drive cooperative intermolecular oncogene expression. "This is a paradigm-shift. Here we show that ecDNA hubs, comprised of ~10-100 ecDNAs clustered in the nucleus of interphase cells, drive intermolecular enhancer input … ecDNA hubs drive cooperative intermolecular oncogene expression. 11 月 24 日，斯坦福大学 HowardChang 教授团队在《 Nature 》发表了题为 “ecDNAhubs drive cooperative intermolecular oncogene expression” 的论文，他们研究了致癌 ecDNA 的细胞核空间、表观遗传因子和转录调控，发现聚集在间期细胞核中的 ecDNA 可以 “ 抱团行动 ” ，驱动分 … 2021. New data challenge the view that only oncogene dosage is affected by ecDNA, and raises the possibility that ecDNA could disrupt genome-wide gene expression. Cite. ecDNA hubs drive cooperative intermolecular oncogene expression. Follow Posted on 21.09.2021 - 21:19 by Kathryn Yost Article 24 NOV 21 Extrachromosomal oncogene amplification in tumour pathogenesis and evolution. [Google Scholar] Gorman CM, Howard BH, Reeves R. Expression of recombinant plasmids in mammalian cells is enhanced by sodium butyrate. “ecDNA hubs drive cooperative intermolecular oncogene expression.” Nature. ... Circular ecDNA promotes accessible chromatin and high oncogene expression. 2021. Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer 1,2, but our understanding of the structure of ecDNA and its effect on gene regulation is limited.Here, by integrating ultrastructural imaging, long-range optical mapping and computational analysis of whole-genome sequencing, we demonstrate the structure of circular ecDNA. EcDNAs could be clustered together within the nucleus, which can be referred to as ecDNA hubs. The shape of cancer ecDNA is … [Europe PMC free article] ... ecDNA hubs drive cooperative intermolecular oncogene expression. Gorkin, D. U., Leung, D. & Ren, B. View author publications You can also search for this author in PubMed … Extrachromosomal DNA (ecDNA) amplification has been observed in at least 30 different cancer types and is associated with worse patient outcomes. Moreover, … Cancer Sciences Location: Southampton General Hospital Salary: £31,406 Full Time Fixed Term (until 30/09/2022) Closing Date: Monday 06 December 2021 Reference: 1616921CM Applications are invited for a Post-doctoral Research Fellow to join the Cancer Genomics Research Group in the School of Cancer Sciences. Here I describe the Circle-Seq protocol, applicable for physical enrichment of eccDNAs of a broad size range, combined with sequence confirmation of circular structures.Briefly, by concise alkaline treatment and gentle gravity flow-through an ion … Save to Library Save. Article 24 NOV 21. Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Cancer Sciences Location: Southampton General Hospital Salary: £31,406 Full Time Fixed Term (until 30/09/2022) Closing Date: Monday 06 December 2021 Reference: 1616921CM Applications are invited for a Post-doctoral Research Fellow to join the Cancer Genomics Research Group in the School of Cancer Sciences. ecDNA hubs drive cooperative intermolecular oncogene expression. SHOWING 1-10 OF 10 REFERENCES. Article 24 NOV 21. ... ecDNA hubs drive cooperative intermolecular oncogene expression. In light of this, ecDNA has been found to be circular and drive massive expression of oncogenes in ecDNA. Nature 575, 699-703 (2019). Article 24 NOV 21. Cassandra Willyard 0 Cassandra Willyard Cassandra Willyard is a science journalist based in Madison, Wis. View author publications You can also search for this author in PubMed Google Scholar Twitter 11 月 24 日，斯坦福大学 HowardChang 教授团队在《 Nature 》发表了题为 “ecDNAhubs drive cooperative intermolecular oncogene expression” 的论文，他们研究了致癌 ecDNA 的细胞核空间、表观遗传因子和转录调控，发现聚集在间期细胞核中的 ecDNA 可以 “ 抱团行动 ” ，驱动分 … The oncogene amplification in the form of ecDNA. Alterations to gene regulatory plexuses typify oncogenesis, and two recent studies from Hung, Yost, Xie et al. New data challenge the view that only oncogene dosage is affected by ecDNA, and raises the possibility that ecDNA could disrupt genome-wide gene expression. EcDNA hubs drive cooperative intermolecular oncogene expression cancer biology more details view paper. doi.org. Tjian R, et al. Mol Cell Biol. Save to Library Save. Usha Lee McFarling 0 Usha Lee McFarling Usha Lee McFarling is a Pulitzer Prize–winning science and medical writer based in Los Angeles. Article 24 NOV 21. Image files for Hung*, Yost*, Xie*, et al. Although there is still much to work out about how ecDNA hubs drive oncogene expression and cancer evolution, and in what cancers these interactions are important, as the hubs are held together by proteins (such as BRD4), it is possible that these could be targeted therapeutically. ecDNA is prone to unequal segregation to daughter cells, suggesting that it may induce a rapid genetic heterogeneity. This may not be the complete list of references from this article. Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation. and Bay, ... ecDNA hubs drive cooperative intermolecular oncogene expression. Expression profiling of macrophages reveals multiple populations with distinct biological roles in an immunocompetent orthotopic model of lung cancer. Hung, Yost, Xie et al. have shown that ecDNAs are held together in hubs in the nucleus and that intermolecular interactions between ecDNAs can enhance oncogene expression. Thus, ecDNA hubs are nuclear bodies of many ecDNAs tethered by proteins and platforms for cooperative transcription, leveraging the power of oncogene diversification and combinatorial DNA interactions. We suggest ecDNA hubs, rather than individual ecDNAs, as units of oncogene function, cooperative evolution, and new targets for cancer therapy. Developing new diagnostics and therapeutics for personalised cancer treatment. Nature. Structural basis for ligand reception by anaplastic lymphoma kinase. Structural basis for ligand reception by anaplastic lymphoma kinase. Article 24 NOV 21
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