Just looking at success rates with IUI that I read on this forum I thought that my doc was wrong. The IUI that I went though with with 6 mature follicles failed but it gave us the confidence to move forward with IVF (we traveled from the USA to the Czech Republic for affordability, here's my blog if you want to read more about our IVF abroad experience: https://gettingpraguenat.travel.blog/) We had success with our first round of IVF and I'm currently 6w pregnant. Although many researchers have reported the success rate of IUI, not many have correlated specific variables with the success of IUI treatment. IUI With Fertility Medications . "Early on, follicular growth may be minimal, but once the follicle(s) have committed to 'active' growth, then they may grow 1-3 mm per day." The number of follicles produced is also dependent on the treatment option. Rupture of follicles should ideally happen on D14 - 15, 36- 48hrs after HCG injection but it may also happen latter. IVF has a much faster time to pregnancy due to it's higher success rate per cycle. IUI is typically only used for up to three or four cycles — chances of success drop off after that. If the count was above 9 million the same chances of success were observed. Is a 22mm follicle good for IUI? The success drops as sperm #s go down. However, the maximum pregnancy rate, 62.5 % was observed in the group with follicular size, 14.1-16.0 mm (Table 1). I was hoping for a better response. The more follicles you have, the higher the risk of multiple births and the higher the risks to the health of the babies and the mother. Tips For A Successful IUI 5, May 2020), "Mature Follicle Count and Multiple Gestation Risk Based on Patient Age in Intrauterine Insemination Cycles with Ovarian Stimulation" (Evans et al) evaluated the risk of multiple level pregnancies by age group and the number of mature follicles obtained related to the use of COH-IUI treatment. IUI success over 40. Triplets or more occur in less than 1% of IUI cycles. Women aged 35 to 37 have a 14% success rate and the birth rate for women aged 38-39 is 12%. The overall success rate of IUI is depending on many aspects. If you decide to go forward with IUI, here are some useful hints that will improve your chances of success. ( 17 ) reported similar results, with pregnancy rates of 7.6% for one follicle, 10.1% for two follicles . Using fresh (that is, not frozen) eggs or . Good luck to you! One or 2 follicles are ideal. As a general guideline, however, antral follicle counts can be used to help determine the likelihood of success for ovarian stimulation and IVF, and may also be used to guide dosing for fertility medications. But I've gotten pregnant naturally before, and this time, it's been well over two years. WHAT ARE THE FACTORS AFFECTING IUI SUCCESS? Hi, Usually the success rate of intrauterine insemination (IUI) is around 20% according to the literature. right before eggs released and one sun. No. Plosker and Amato showed that recruitment of at least two follicles increased success rates in COH in combination with IUI-by 2% for one follicle, and by 15% for two or more follicles (p < 0.01). Antral Follicle Count was 34, and FSH is 4.9. In HMG cycles, the number of follicles decreased with age, from 7.3 before age 28 to 3.5 for ages 42 to 43. Women ≥ 40 years old. Good chances. IUIs generally have a success rate of around 5-20% per cycle. Can you get pregnant with 4 follicles? Double IUI means insemination is done twice. Three + follicles IUI: Success rates of 16% and 17% per cycle. Patients with follicular size between 14 and 22 mm had the positive outcome. If an IUI is to be successful it most often happens in the first three or four treatment cycles [1] [2] . [1,2,3,4] Besides the relatively low success rates, another problem with IUI is the risk for multiple gestations, especially high order multiple gestation, when the growth of multiple follicles is . Therefore, depending on every case, there can be a very good IUI success rate with even just one follicle. Generally, IVF success rates are better than IUI rates. Decided to use two vials to increase the sperm count. The second pregnancy, I only had one follicle and now I'm 33wks along. This happens due to a drop in the conception rate. Apr 20, 2017 at 4:42 PM. My DH said what the hell after everything we have been through in the past year and then the doctor agreed. When values were below critical levels of six or more follicles >12mm, four or more follicles >15mm, and E2 levels >1000 in HMG and clomiphene + HMG cycles - and six or more follicles >12mm in CC cycles - triplet and higher-order implantations occurred in less than 1% of cycles and in less than 5% of pregnancies. However, women over 40 have just 5% or lower chances of per-cycle success. Over the age of 40, the success rates with IUIvary with declining age from around 6-7%. #2 Rags, Aug 12, 2011. monalisa81 Well-Known Member. But reported success rates vary quite a bit from study to study. Men must refrain from ejaculation for at least 3 days before IUI. Medication (progesterone) is also administered to prepare the woman's uterine lining for implantation of the fertilized egg. Last month I was on 37.5, and only had one mature follicle. An IUI with injectibles would be closer to $1500. IUI with fertility medication (Clomid): average success rates range from 8% to 15% per cycle for patients under 35 to 2% to 5% for patients over 40. This proves that more the cycle is performed better the chance of conception. Increasing the number of mature follicles from one to five at the time of IUI in women younger than age 38 years increased the clinical pregnancy rate from 14.6% to 21.9% (adjusted odds ratio [aOR] 1.6, 95% CI 1.4-1.9), almost entirely from a marked increase in multiple gestations per cycle from 0.6% to 6.5% (aOR 9.9, 95% CI 6.9-14.2). Each cycle I had good response with 3 mature follicles on various sides and greater than 50 million sperm per sample. IUI has a ten per cent to thirty per cent success rate. Hopefully your doctor might have followed Comment. If the leading follicle was found to be less than 10µm by day 8 or 9, a 50% increase in dosage was prescribed. right before eggs released and one sun. Now, a new retrospective study involving more than 37,000 patients and said to be the largest to date to examine the relationship between IUI and post-wash motile sperm numbers concludes that a motile sperm count of ≥9 x 106 gives the best chance of success (with a pregnancy rate per cycle of 16.7%). (1) The pooled OR for the pregnancy rate after five follicles as compared with monofollicular growth was 2.8 (95% CI 2.1-3.8). But, you wouldn't want to use a more invasive, expensive fertility treatment if you don't need to. Hence, I was going to post a question about success rates without injectables and clomid. SO also has a very high count (99 to 104 million), but slight morph issues. Got my BFP 12 days piui. According to your follicular study reports endometrial thickness of 11 mm, can be considered as normal and good. Success rates with Clomid and intrauterine insemination (IUI) vary depending on a woman's age and the cause for infertility. The pregnancy outcomes of IUI are showed in Table 2.Higher clinical pregnancy rates were showed in the HMG induced cycles of both one (9.75%, P < 0.05) and two (11.46%, P < 0.05) follicles compared with the natural cycles (127/1716, 7.4%).The live birthrate was increased in HMG induced cycles, but there was no difference or improvement compared with the natural cycles in either single or two . If the couple performed IUI each month the success rate will increase by 20 percent. When evaluating the full cohort, the mean clinical pregnancy rate (CPR) per IUI ranged from 13.0% with 1 mature follicle to 19.6% with 5 mature follicles. Sorry I've no other details but all the best to you. However, don't refrain for more than 5 days since that can negatively affect your chances of getting pregnant. cycles. Artificial insemination success rate for spousal insemination. At that point, other treatments (like IVF) will usually be explored. The risk of having a twin pregnancy following the use of injectable hormones and IUI is about 20%. The rates of IUI success tend to be higher when fertility drugs are used compared to cycles that are done without fertility drugs. As a result, the success rate can range from 2% to 22% per cycle depending a variety of factors: Number of follicles Ovarian stimulation protocols and medications used Cause and duration of infertility The major differance being that the injectibles alone would cost $500 - $1000, plus they do 3 u/s instead of 1. : Hi ladies - it's been a while since I've been on here but we haven't been able to 'try' since our last failed IVF cycle and I find it really difficult to be on here when I don't have a chance, however small, of conceiving. 10.1% 8.2% 6.5% 3.6% 0%. It is very likely that the woman will not get pregnant in the first artificial insemination. As a general guideline, however, antral follicle counts can be used to help determine the likelihood of success for ovarian stimulation and IVF, and may also be used to guide dosing for fertility medications. Now the wait begins. As a result, the brain produces more follicle stimulating hormone (FSH), which stimulates the growth of multiple follicles. The one questionable factor was the the Clomid seemed to thin my . Feeling optimistic but trying not to get my hopes up since plenty of people still get BFN with 5 follicles. IVF using a woman's own eggs: average success rates range from 40% to 45% for patients under 35 to 15% or less for women over 42. Both single and double IUI have similar pregnancy rates therefore single IUI is more commonly practised as it is more practical. For women under 40 years of age, IVF is recommended once three cycles of IUI have failed to result in pregnancy. Success. When the blockage is closest to the ovary, the success rate of IUI is 11.7%. However, most of the private centers are concentrated in Lagos and Abuja. However, once the sperm count dropped below 9 million, so did the success rates. I was on clomid 100 mg and had 1 follicle. The success rate of the IUI procedure varies through each cycle as the rate increase by 20% per cycle. Wanttomeamommy. The first month after the failed IVF was over the Christmas holidays and the office is closed. Clinical pregnancy rate in IUI cycles when using clomiphene citrate or another go-nadotropin for ovulation induction is about 12% but in 15 to 30 is considered a good number. My dr would not even do IUI if you had more than 2 or 3 follicles, and he thought it was wreckless of drs who did. A recently published study in Obstetrics and Gynecology (Vol. My scan today showed 3 follicles - 2.4 cm, 1.5 cm and 1.5 cm. Abstain from Male Ejaculation for 3 Days Pre-Treatment. . IUI success rates vary by a woman's age, which drugs (if any) accompany the cycle, and how many follicles grow during the cycle. "The peak IUI effect is around three to four cycles," says Baratz. In women age 35-39 (n=543), optimal pregnancy rates (34.8%) were achieved with 5-9 eggs at retrieval. Two + follicles IUI: Success rates of 9%, 13% and 21% per cycle. "The rate of follicular growth is dependant on the phase of the stimulation cycle," explained Dr. Timmreck. Sperm motility and morphology is really important for the success of IUI as well as getting the correct timing, if you're doing unmedicated IUI. Jun 25, 2020 — Antral Follicle Count (AFC) - Every month, inside the ovaries, a group of eggs from the microscopic ovarian reserve begins to grow at least 2mm.. One follicle IUI: Success rates of 3%, 4% and 8% per cycle; Two + follicles IUI: . I am in the exact boat as you. The table above shows results from one large study of IUIs using Clomid. First IUI is done at 24 hours and second IUI at 48 hours after HCG injection. This injection triggers ovulation of mature follicles. We were successful and turns out only one took. Usually, women have the IUI success rate of 10-20 percent in the first try of intrauterine insemination cycle. 135, No. "If you're going to get pregnant [with IUI], you'll get pregnant within those attempts." On an average success of IUI is 9-15% per cycle. Unlike IVF or ICSI, IUI is a more variable procedure that can involve different ovarian stimulation and semen preparation protocols. The success rate of IUI treatment in Kota is based on various aspects including the fertility drugs used, the age of woman and the type of infertility. I had one mature follicle and one other that looked too small, and got pregnant with twins with IUI. My husband and I are very nervous about twins. a. avefav. The main goal of IUI is to get the best quality sperm closer to the egg prior to ovulation. On the other hand, there is a significant drop in IUI success to 5.6% when women continue on to 4-6 cycles. IVF success rates are much higher - about 20% at age 41 in our IVF program. Ideal Sperm count is 10 million post wash. 5-10 million average < 5 million the pregnancy rates are less. IUI in heterosexual couples under the age of 35, achieve a success rate between 10 and 15% per cycle, between 36 and 39 it is approximately 10%. On average 5 - 15% of IUI cycles lead to a live birth with gonadotropin (injectable drug) cycles performing best followed by clomid or letrozole cycles . Most studies have shown a success rate (delivery of a baby) at age 41 of about: 1-2% per month with Clomid + IUI. Ended up with 15 million with 34% motility. IUI is a simple treatment and its success rate is slightly higher than natural pregnancy. Oct 15, 2012, 4:22:03 PM. 2-4% per month with injectables + IUI. Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar. Across all patients types, IUI cycles have live birth rates per cycle of between 5 - 15%. In clomiphene + HMG cycles, the number of follicles decreased from 5.8 before age 28 to 3.3 for ages 42 to 43. Had my iui on Feb 18 and 19. pregnant with IUI can vary based on your age. Hence you stand more than 20 percent chances of success. This increases the amount of semen which further helps to provide a good sperm count for the treatment. So, I'd say that it doesn't really matter what clinic you go to (unlike IVF where the lab is very important). The number of studies that reported on pregnancy rates after six follicles or more, as well as the number of patients in these categories, was limited, making meta-analysis not useful. The singleton rate per IUI increased by only 1.9% from 12.4% with 1 follicle to 14.3% with 5 follicles, while the odds of multiples increased by a factor of 8.6 (aOR 8.6, 95%CI 6.2-11.8 . Dr. Jeff Livingston answered. 15 to 30 is considered a good number. How is IUI Semen Sample Prepared? The success rate for IUI I do not know how much, but one thing I know there are couple ladies in this forum did success conceived 1st, 2nd, or 3rd IUI so there is chance there. While pregnancy can happen, the success rate depends on the blockage's location on the blocked tube. The implantation rates per follicle were identical for all three stimulation regimens and decreased sharply after age 39. Number of cycles: IUI success rates are highest in first one or two cycles depending on study, stats not shared. My DH and I went to the doctor today to see how many mature follicles had produced for IUI. The only thing they can point to is that I ovulate late in a cycle, around Day 19. 2nd round of IVF stims. Because the success rate of IUI is low, many couples failing IUI subsequently .. Today is day 5 of stims on 2nd round with new protocol--mini-lupron flare protocol--and I only have 5 follicles. The sperm quality, the egg quality, the age of . IUI #4 or 5 (can't remember) with 5 mature follicles. Obstetrics and Gynecology 23 years experience. In various studies has been done chance of pregnancy in infertile couples with ovulation induction and IUI had a significant increase [4, 5]. What is the iui success rate with 2 follicles and donor sperm? rate of pregnancy despite appropriate size of follicle (12). I guess a better question is about IUI pregnancy rates with only one follicle. Clinics will do everything possible to improve chances . However, most ladies who use IUI also use injectables. Research shows IUI done with at least 9 million motile sperm had a 17% success rate. Nonetheless, the optimization of volume used in dIUI should be equally important in patients who undergo IUI because of mild male factor infertility or other indications. Therefore, depending on every case, there can be a very good IUI success rate with even just one follicle. IUI success chances by age: Age is a crucial factor determining the odds of IUI success. Superovulation might not be successful in women over age 40 and women diagnosed with primary ovarian insufficiency (also known as POI or premature ovarian failure).
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